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KMID : 0882420080740020146
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Korean Journal of Medicine
2008 Volume.74 No. 2 p.146 ~ p.153
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Expression of claudin-1, β-catenin and E-cadherin in adenocarcinoma of the colon
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Cha Eun-Jung
Kim Kyung-Ryoul
Jang Kyu-Yun
Lee Dong-Geun
Kang Myoung-Jae
Choi Keum-Ha
Choi Ha-Na
Moon Woo-Sung
Hwang Sung-Ho
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Abstract
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Background : Disruption of the cell-to-cell junction with changes in the expression of the junctional proteins is the hallmark of cancer invasion and metastasis. To investigate the roles of claudin-1, β-catenin and E-cadherin in adenocarcinoma of the colon, the relationship of their expression with clinical and pathological factors were examined.
Methods : The expression of claudin-1, β-catenin and E-cadherin were examined in 47 cases of adenocarcinoma of the colon by immunohistochemical staining.
Results : A reduced claudin-1 expression was associated with advanced lymph node metastasis (p=0.019) and histological dedifferentiation at the invasive front (p=0.030). A reduced expression of β-catenin and E-cadherin were correlated with histological dedifferentiation (p=0.012, p=0.010, respectively). The reduced expression of two or more proteins was correlated with the histological findings of dedifferentiation (p=0.030).
Conclusion : These results suggest that loss of claudin-1, β-catenin and E-cadherin expression may be correlated with the progression of adenocarcinoma of the colon and associated with an advanced histological grade.
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KEYWORD
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Colon, Adenocarcinoma, Claudin 1, beta Catenin, E-cadherins
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